I have exactly the same problem, in a VM in Xenserver, perfectly reproducible. The working system is based on an Ubuntu Server 16.04 64 Bit Beta 2, once I upgrade, X2Go stops working, with the same kind of error message. Apr 19 17:39:27 [] /usr/bin/x2goruncommand: launching session with Xsession-x2go mechanism, using STARTUP="mate-session" Apr 19 17:39:29 [] mate-session[14491]: GLib-GIO-CRITICAL: g_settings_schema_source_lookup: assertion 'source != NULL' failed Apr 19 17:39:29 [] mate-session[14491]: GLib-GIO-ERROR: No GSettings schemas are installed on the system#012aborting... Apr 19 17:39:29 [] kernel: [ 1862.499144] do_trap: 12 callbacks suppressed Apr 19 17:39:29 [] kernel: [ 1862.499148] traps: mate-session[14491] trap int3 ip:7fe0b30e49eb sp:7ffd7ec9adb0 error:0 Once I revert to a snapshot before the upgrade, X2go works again, upgrading one more time and it fails again.. Attached are lists of packages and version before and after the upgrade, maybe that helps. Kind regards, Rudolf